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In vitro studies have characterised its effects on antioxidant enzyme expression profiles and melatonin biosynthesis pathway regulatory mechanisms in cell line models

Pathological Consequences of Glutamate Excitotoxicity In general, an excess or prolonged exposure of neurons and glia to high levels of extracellular glutamate during ischemia both lead to a massive Ca 2+ entry into the cells of both gray and white matter (Danysz and Parsons, 2003

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