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Concurrent nutritional deficienciesparticularly folate or iron deficiencycan impair the response to B12 treatment, as these nutrients work together in red blood cell production

the clinical significance in humans remains under investigation and is not yet established for retatrutide specifically [24] [25] Other class-associated cautions: Based on the broader GLP-1/GIP receptor agonist class, potential effects on gallbladder function and delayed gastric emptying are relevant considerations, though evidence specific to retatrutide is still emerging It is important to note that this evidence derives from early-phase trials conducted under controlled conditions with medical supervision

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While diet provides enough B12 for most, some medical conditions prevent proper absorption, making injections necessary