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Similar content being viewed by others Introduction The airway epithelium, composed of basal cells, multiciliated cells, club cells, goblet cells and several rare cell types, is the primary site for pulmonary diseases including chronic obstructive pulmonary disease (COPD), the third cause of death in the world by 2030 according to the prediction by WHO ( Tobacco smoking can cause airway epithelial remodeling including multiciliated cell hypoplasia, goblet cell hyperplasia and mucus overproduction and is the leading cause of COPD