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[1] NNMT as a Metabolic Research Target Independent research groups have studied NNMT inhibition in diet-induced obese (DIO) mouse models

[1] Because intrinsic-factor-dependent uptake in the distal ileum can be absent in conditions such as autoimmune gastritis, pancreatic insufficiency, or bariatric surgery, the intramuscular or subcutaneous route bypasses gastrointestinal barriers and reliably restores serum concentrations

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An interesting finding from the study was the rapid reduction in lameness observed in rabbits receiving the combination of AOD9604 and HA, with full recovery noted in approximately 11 days