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The risk-based approach for evaluating newly obtained HBM data is challenging and requires information on relationships between biomarker concentrations and mycotoxin intake from human and/or animal studies or toxicokinetic modelling, as well as toxicity profiles including mode of action

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Wide-ranging impacts might result from the remodelling of tissues that control metabolic and endocrine processes

However, our included studies intervening with a dosage higher than 2000mg/d seemed to show more benefit to patients [9,10], while one subgroup [9] with 1500mg/d showed less reduction in VAS (p value not provided)