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This drug blocks the action of acetylcholine (anticholinergic effect) and is used as a sedative because it causes drowsiness

Our sample is large (734 CHR individuals, from an initial pool of 1,012 participants including controls) and drawn from eight sites across North America, enhancing generalizability

Smokeless tobacco products work differently, but they deliver the same class of damage through direct absorption in the mouth and throat

However, key confounding variables such as lipid levels, diabetes, weight, body mass index and blood pressure were not included because their role in longevity was not understood at the time the study was designed and this is a limitation of the analysis