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The data were obtained from subjects of varying ages and exposure levels, making them representative of the general population

2 Materials and methods 2.1 Protocol and registration This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement (Moher et al., 2009) and the guidelines from the Cochrane Handbook for Systematic Reviews of Interventions (Higgins and Green, 2008)

Understanding tirzepatide's mechanism of action is essential for anticipating potential side effects, as many adverse reactions relate directly to its effects on the gastrointestinal system and glucose metabolism

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