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In an RCT of 44 youth assigned to lithium only or lithium + tamoxifen 2040 mg, the augmentation with tamoxifen group had significantly more 50% reduction proportion in the active treatment augmentation group for mania ratings compared to placebo augmentation (Talaei et al., 2016), due to the observation that in cancer cohorts mood symptoms worsen with long-term tamoxifen use in those predisposed to depression (Kishi et al., 2022)

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To mimic PCOS conditions, KGN cells were treated with 500 nM dihydrotestosterone (DHT) for 24 h [21]

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