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In summary, there remain three bottlenecks for clinical breakthroughs, as follows, the low bioavailability of natural products should be improved, the combined application of two or more compounds should be investigated for more prominent pharmacological effects and the evidence of clinical efficacy of other compounds requiring further confirmation

doi: 10.3390/nu13030856 90 HouYGuDPengJJiangKLiZShiJet al

[PubMed] [Google Scholar] 101.Roy U., Barber P., Tse-Dinh Y.C., Batrakova E.V., Mondal D., Nair M

*Correspondence: Yi Hua, [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers