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No lethal dose has been established, and animal models show a very high safety threshold

FDA's evaluation concluded that the criteria weighed against placement on the list, citing inadequate physicochemical characterization, immunogenicity concerns from impurities and aggregates, lack of clinical effectiveness data for any approved use, and absence of published human exposure data for the proposed subcutaneous and topical routes

Angiogenesis & Repair: Studying the combined impact on Extracellular Matrix (ECM) remodeling

Structural tissue remodeling continues through weeks eight to twelve, with objective imaging improvements typically visible at the eight-week mark when applicable