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Tirzepatide is a dual GIP/GLP-1 receptor agonist with a 5-day half-life, meaning it takes approximately 25 days (3-4 weeks) for the medication to be substantially eliminated from your body after your final injection

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Once activated, ERK1/2 is transferred to the nucleus, where it phosphorylates transcription factors such as c-Myc and c-Fos, leading to the expression of genes responsible for cellular regulations such as cell proliferation, differentiation, and migration

doi: 10.1038/s41574-023-00816-5 240 Evans-MolinaCDorYLernmarkMathieuCMillmanJRMirmiraRGet al