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In preclinical models, Dihexa demonstrated superior pharmacokinetic properties, including good oral activity and effective BBB penetration, along with enhanced metabolic stability with a half-life of 335.5 minutes

available clinical trial data suggest the compound supports once-daily dosing, implying a half-life of many hours, but a precise figure is not reliably citable from the public literature

Until retatrutide receives regulatory approval, NICE guidance on weight management directs clinicians towards licensed options within established care pathways

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