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10.1186/s12951-016-0164-2 Summary Keywords tobacco and tobacco product, nicotine-containing products, new approach methodologies (NAMs), regulatory flexibility, toxicity testing, in vitro , in silico Citation Miller-Holt J, Behrsing HP, Clippinger AJ, Hirn C, Stedeford TJ and Stucki AO (2022) Use of new approach methodologies (NAMs) to meet regulatory requirements for the assessment of tobacco and other nicotine-containing products

FDA-approved medication and cessation counseling are effective when used by themselves for treating tobacco dependence

Its a pernicious effect that tends to result in more intense cravings for cigarettes, thus reinforcing the vicious circle of nicotine addiction

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