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For researchers designing dose-response experiments, signaling pathway studies, or preclinical tissue models, the purity of the peptide preparation is a fundamental experimental variable one that, if ignored, can produce data that cannot be replicated or interpreted correctly

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Moreover, the communication between MAMs and the coordination of Ca 2+ flux from the ER to mitochondria are pivotal for triggering oxidative metabolic stress, a ROS surge, and an ensuing pro-paraptotic Ca 2+ overload in breast cancer cells [153]

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