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In obese mice, chronic administration of AOD-9604 was shown to significantly increase 3- adrenergic receptor (3-AR) mRNA expression in both white and brown adipose tissue

Study 3: Combination With Diet Independent work showed that NNMT inhibition plus a lean/low-fat diet accelerated weight and fat loss beyond diet alone, improved the lean-mass-to-body-weight ratio, and ameliorated obesity-linked liver pathologies

The Journal of clinical endocrinology and metabolism , 82 (5), 14721479

(1) More specifically, AOD 9604 is considered the lipolytic fragment of GH as different parts of the GH molecule appease to have different potentials