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Timing Optional Monitoring guidance is pathway-based and broad because NAD+ protocols do not have established clinical lab-response markers

For example, endocrine experts caution that the age-related GH decline might even be protective (theres ongoing debate), and artificially raising hormone levels in someone without deficiency could do more harm than good

These properties account for its extensive investigation in dermatology and wound-healing models

A patient may need a topical cream when only oral capsules are available in the needed hormone, or a sublingual preparation when they cannot tolerate oral delivery